Pancragen dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 7 published studies are one click away.
Animal studies only Bioregulators Also called KEDW, Lys-Glu-Asp-Trp-NH2, pancragene
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Two community guides agree on 10 to 20 mg a day by mouth for 10 to 30 days, repeated every 3 to 6 months. Neither gives an injected amount. Sources are community and vendor guides only. No approved label exists in any country we found, and the published research comes almost entirely from one Russian research group.
Sources disagree, or there are very few. The amounts below come from a small number of guides, and they do not line up well. Treat every number on this page as uncertain, and check each source yourself.
- Half-life
- Not measured in any published study
- How it is taken
- Shot under the skin (subcutaneous), or oral capsule
- How long people use it
- 10 to 20 days in a row, then a break. The course is repeated every 3 to 6 months, which works out to 2 or 3 courses a year.
Includes amounts taken by mouth or in the nose. Those are not the same as a shot, see the route in each row below.
| Tier | Each dose | Syringe units | How often | Schedule | Vial lasts |
|---|---|---|---|---|---|
| Oral Typical [1] | 10 mg | Not a syringe dose | once a day | 10 mg by mouth once a day, the low end of the 10 to 20 mg range, for 10 to 30 days. | |
| Oral Higher [2] | 20 mg | Not a syringe dose | once a day | 20 mg by mouth once a day for 20 to 30 days. | |
| Oral Maintenance [3] | 10 mg | Not a syringe dose | once a day | 10 mg by mouth once a day for 10 days, every 4 to 6 months. |
Good to know
- Taken by mouth once a day.
- Oral strengths vary a lot by maker. Some packs list capsules, not milligrams, so the label on the box matters more than any range here.
- No injected amount is given in the guides. Injectable vials are sold, but with no common dose attached.
Sources for these amounts
- Oral Typical: Peptide Assistant, Pancragen · Peptide DB, Pancragen
- Oral Higher: Peptide Assistant, Pancragen · Peptide DB, Pancragen
- Oral Maintenance: Peptide Assistant, Pancragen · Peptide DB, Pancragen
How long people use it: Peptide Assistant, Pancragen · Peptide DB, Pancragen · Khavinson bioregulator guide (IPS News)
Half-life: Goncharova et al, Adv Gerontol 2014 (monkey study, no PK)
Take the Pancragen chart with you
Get a one-page printable chart for Pancragen, with the syringe units for each vial and water mix. We can also email you when a new Pancragen study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 7 published studies
No human dose data. No published human study of Pancragen states an amount given. Every figure on this page comes from animal studies.
Amounts given to animals in studies
Read this first. A human study in 33 older adults with type 2 diabetes exists, but its abstract gives no amount. Rat studies give no amount in the abstract. Monkey doses are per animal, not per kg. Only two small monkey studies from one group.
Every study used for this page
Proof grade: Animal studies only. No human dose data has been published. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 22448364Korkushko et al, Bull Exp Biol Med 2011 | Human, 33 older adults with type 2 diabetes (plus 30 healthy older controls) | Not stated in the abstract | Not in abstract | Not in abstract | Not in abstract | Lowered fasting glucose, insulin and insulin resistance index in the diabetes group. No change in untreated patients |
| PMID 25946840Goncharova et al, Adv Gerontol 2014 | Rhesus monkey, old females (n not in abstract) | 50 mcg per animal per day | Into the muscle | Once a day | 10 days | Faster glucose clearance and normal insulin and C-peptide response. Effect partly lasted 3 weeks after stopping |
| PMID 28509500Goncharova et al, Adv Gerontol 2015 | Rhesus monkey, 9 old females (5 on pancragen, 4 on glimepiride) | 0.05 mg per animal per day | Into the muscle | Once a day | 10 days | Lower basal glucose, normal insulin and C-peptide. Milder than glimepiride 4 mg by mouth |
| PMID 18642713Khavinson et al, Bull Exp Biol Med 2007 | Rat, Wistar with streptozotocin diabetes (n not in abstract) | Not stated in the abstract | By mouth and into the muscle (separate arms) | Not in abstract | Not in abstract | Oral form lowered blood glucose during treatment. Injected form normalised capillary adhesion |
| PMID 16671579Khavinson, Bull Exp Biol Med 2005 | Rat, alloxan diabetes (n not in abstract) | Not stated in the abstract | Not in abstract | Not in abstract | Not in abstract | KEDW-NH2 partly restored insulin synthesis. Sugar curve similar to normal animals |
| PMID 17152728Zakutskii et al, Adv Gerontol 2006 | Rat tissue explants, young (3 week) and old (18 month) | 0.05 ng/ml | Added to culture | Not in abstract | Not in abstract | Stimulated growth of pancreas explants in young and old rats |
| PMID 23734516Khavinson et al, Adv Gerontol 2012 | Human aged pancreatic cell cultures | Not stated in the abstract | Added to culture | Not in abstract | Not in abstract | Raised proliferation and function markers, lowered p53 in aged cells |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
Is there a human dose for Pancragen?
No published human study of Pancragen states an amount given. The figures on this page come from animal studies only.
Where do these Pancragen numbers come from?
From 7 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Animal studies only.
How long does Pancragen stay in the body?
No published study has measured the half-life of Pancragen, so nobody knows exactly how long one dose stays in the blood.
Is this a recommendation for how much Pancragen to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.