Semax dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 7 published studies are one click away.
Small human studies Brain
Common use ranges
Mostly from the official drug label or its main trials, plus clinic protocols. Nasal doses match the Russian label well. Injected doses agree on 0.3 to 0.8 mg a day but come only from clinics and vendor guides.
- Half-life
- Not measured in any published study
- How it is taken
- Nasal drops (the original route, a registered drug in Russia). Some people inject it under the skin.
- How long people use it
- Nasal label courses are short: 3 to 5 days for fatigue, 10 to 14 days for other uses, repeated if needed. Injected use runs longer, often 4 to 8 weeks on, then the same time off. One clinic does 2 months on, 2 months off.
- Mixing used for the units
- 10 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 50 mcg.
Pick your vial size and how much water you add. The units below change to match.
10 mg vial + 2 mL water: 1 unit = 50 mcg
| Tier | Each dose | Syringe units10 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Nasal, label (0.1% drops) [1] | 200 mcg | Not a syringe dose | 2x a day | 2 to 3 drops in each nostril, 2 to 3 times a day, in the first half of the day. One drop of the 0.1% solution holds 50 mcg, so one dose is 0.2 to 0.3 mg. Daily total 0.4 to 0.9 mg. | |
| Nasal, typical [2] | 300 mcg | Not a syringe dose | 2x a day | 200 to 300 mcg per dose, twice a day (morning and early afternoon), for 10 to 14 days. One guide allows up to 600 mcg per dose, 2 to 3 times a day. | |
| Injected, starting [3] | 300 mcg | 6 units 0.06 mL | once a day | 300 mcg once a day in the morning for the first 1 to 2 weeks. | about 5 weeks |
| Injected, typical [4] | 500 mcg | 10 units 0.10 mL | once a day | About 500 mcg once a day in the morning. One clinic uses 0.5 mg on 5 days a week for the first 2 weeks. | 20 days |
| Injected, higher [5] | 800 mcg | 16 units 0.16 mL | once a day | Up to 800 mcg once a day by weeks 3 to 8. One clinic gives it 5 days on, 2 days off. | 12 days |
Good to know
- Semax is a registered drug in Russia as 0.1% and 1% nasal drops in 3 mL bottles. The 1% drops are for stroke and use much bigger doses.
- Nasal mg depends on drop size. The label says 50 mcg per drop for 0.1%. Other sites give different numbers.
- Injecting is not a studied route. Injected doses are copied from nasal ones.
- Most people take it in the morning or before 2 PM.
- Research vials are sold as 5 mg and 10 mg powder.
Sources for these amounts
- Nasal, label (0.1% drops): Semax 0.1% instruction sheet (English translation of the Russian label)
- Nasal, typical: Peptide Dosing Protocols, Semax and Selank stack · Peptide Protocol Wiki, Semax dosing
- Injected, starting: Pure Peptide, Semax 10 mg protocol · Peptide Dosing Protocols, Semax and Selank stack
- Injected, typical: Peptide Dosing Protocols, Semax and Selank stack · Perfect B, Semax injection protocol
- Injected, higher: Perfect B, Semax injection protocol · Pure Peptide, Semax 10 mg protocol · Peptide Dosing Protocols, Semax and Selank stack
How long people use it: Semax 0.1% instruction sheet · Perfect B, Semax injection protocol · Peptide Dosing Protocols, Semax and Selank stack
Half-life: Breakdown of ACTH(4-10) and Semax by rat blood enzymes, 1991 · Kinetics of Semax entry into rat brain and blood after nose dosing, 2006
Take the Semax chart with you
Get a one-page printable chart for Semax, with the syringe units for each vial and water mix. We can also email you when a new Semax study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 7 published studies
Amounts given to people in studies
How it was given: Nose drops
Human studies are small and mostly from Russia.
Amounts given to animals in studies
Read this first. Some animal abstracts say rodent without naming rat or mouse. Those were scaled as rat.
Every study used for this page
Proof grade: Small human studies. Only small or uncontrolled human studies. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 297989832018 | Human, post-ischemic stroke rehab (n=110) | 6000 mcg/day | not in abstract | daily | 2 courses of 10 days with 20-day interval | Raised plasma BDNF, better motor recovery and Barthel index |
| PMID 124598742002 | Human, refractory peptic ulcer (n not in abstract) | 1% solution, 2-4 drops 3 times a day (mg not stated) | intranasal | 3x/day | 10 days | Ulcer healing at day 14 in 89.5% vs 30.8% control |
| PMID 270519262015 | Human, psoriasis plus metabolic syndrome (n not in abstract) | "1% semax solution intranasally 600 mg/day" as printed (likely a typo: 1% is about 10 mg/mL, so mg/day figure is suspect) | intranasal | daily | 10 days | Lipid metabolism correction |
| PMID 91737451997 | Review covering animals and humans | 0.015-0.050 mg/kg | intranasal | single administration | effect lasts 20-24 h | Memory, attention, hypoxia resistance. REVIEW, not a primary trial |
| PMID 163627682005 | Rodents (rats per Neurochem Res; n and wt not in abstract, ~0.25 kg assumed) | 0.15 mg/kg (HIGHEST verified) | IP | single | 1-4 h readout | Striatal 5-HIAA up to 180%, enhanced amphetamine dopamine release |
| PMID 338066922021 | Rat, photothrombosis stroke (n not in abstract, ~0.25 kg assumed) | 25 mcg/kg | intranasal | not in abstract | 7 days | Preserved neurons and PGC-1alpha |
| PMID 414795722025 | Mouse, APP/PS1 Alzheimer model (n not recorded) | 50 mcg per kg | intranasal | frequency not verified | from age 6 months, duration not verified | Semax and derivative tested in Alzheimer model (PMC12755871) |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of Semax were used in human studies?
In the studies listed here, people were given from 1% nose drops, 2 to 4 drops, 3 times a day up to 6,000 mcg per day. The amount used most often was 6,000 mcg per day, 10-day courses. These are what study teams chose for their participants under supervision.
Where do these Semax numbers come from?
From 7 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Small human studies.
How long does Semax stay in the body?
No published study has measured the half-life of Semax, so nobody knows exactly how long one dose stays in the blood.
Is this a recommendation for how much Semax to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.