DSIP dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 8 published studies are one click away.
Human trials Brain Also called delta sleep-inducing peptide, emideltide, Deltaran
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Vendor and compounding guides agree on before bed dosing and a 100 to 500 mcg range. The compounding source starts lower at 50 mcg. No trial has tested shots under the skin.
- Half-life
- Not on the site yet, being checked
- How it is taken
- subcutaneous injection
- How long people use it
- Ranges from 1 to 3 week runs, or only on bad nights, up to 8 to 12 weeks nightly.
- Mixing used for the units
- 5 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 25 mcg.
Pick your vial size and how much water you add. The units below change to match.
5 mg vial + 2 mL water: 1 unit = 25 mcg
| Tier | Each dose | Syringe units5 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 100 mcg | 4 units 0.04 mL | once a day | 50 to 100 mcg, 30 to 60 minutes before bed | 6+ weeks |
| Typical [2] | 200 mcg | 8 units 0.08 mL | once a day | 200 to 300 mcg before bed | about 4 weeks |
| Higher [3] | 500 mcg | 20 units 0.20 mL | once a day | 400 to 500 mcg before bed | 10 days |
Good to know
- Taken 30 to 60 minutes before bed.
- Try one dose for 5 to 7 nights before moving up.
- Going above 100 mcg has not reliably improved sleep.
- Some use 100 to 200 mcg earlier in the day for stress.
Sources for these amounts
- Starting: FormBlends, DSIP dosage protocols · Matrix Advanced Solutions, DSIP · Bio Hack Lab, DSIP 5 mg guide
- Typical: Matrix Advanced Solutions, DSIP · Bio Hack Lab, DSIP 5 mg guide
- Higher: Matrix Advanced Solutions, DSIP · Bio Hack Lab, DSIP 5 mg guide
How long people use it: FormBlends, DSIP dosage protocols · Bio Hack Lab, DSIP 5 mg guide
Take the DSIP chart with you
Get a one-page printable chart for DSIP, with the syringe units for each vial and water mix. We can also email you when a new DSIP study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 8 published studies
Amounts given to people in studies
How it was given: IV (slow injection)
25 nmol/kg is about 0.02 mg/kg. Studies are old (1981 to 2009) and small.
Amounts given to animals in studies
Read this first. Insomnia trials disagree. Early open studies looked good, later double-blind ones found weak or no clinical benefit. Human doses are in nmol per kg, not mg.
Every study used for this page
Proof grade: Human trials. Tested in randomized human trials. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 7028502Schneider-Helmert and Schoenenberger, Experientia 1981 | Human, 6 middle-aged chronic insomniacs | 25 nmoles/kg | IV | One time | One night | Longer, less broken sleep. No daytime sleepiness |
| PMID 3792404Schneider-Helmert, Eur Neurol 1986 | Human, 18 chronic insomniacs (middle-aged and elderly) | 6 x 30 nmol/kg | IV | 6 doses over one week | 1 week, plus 1 week follow-up | Sleep returned to normal values by end of follow-up |
| PMID 3622582Schneider-Helmert, Eur Neurol 1987 | Human, 14 chronic insomniacs, double-blind placebo-controlled | Not stated in the abstract | Injection (route not in abstract) | Nightly | 7 nights | Better night sleep and better daytime alertness |
| PMID 3583493Monti et al, Int J Clin Pharmacol Res 1987 | Human, insomniacs, double-blind crossover | 25 nmol/kg | IV | Nightly | 4 nights | Small sleep gains, judged of little clinical value |
| PMID 1299794Bes et al, Neuropsychobiology 1992 | Human, 16 chronic insomniacs, double-blind parallel groups | 25 nmol/kg | IV | Afternoon before each of 3 nights | 3 days | Weak effects. Not likely of major benefit |
| PMID 7777652Spath-Schwalbe et al, Psychoneuroendocrinology 1995 | Human, healthy young men (n=5 per arm, plus 10) | 3 and 4 mg total | IV infusion | One time | About 2 hours | No effect on ACTH or cortisol |
| PMID 19142086Pomfrett et al, Eur J Anaesthesiol 2009 | Human, 24 women having surgery, randomized (12 on DSIP) | 25, 50 or 100 nmol/kg | IV bolus | Two doses (awake, then under anesthesia) | One surgery | Raised heart rate and lightened anesthesia depth |
| PMID 6379493Kato et al, Neuroendocrinology 1984 | Dog (n=4), plus 1 monkey and 3 rats | 1 or 2 mg | IV | One time | Blood taken every 5 minutes | Cleared fast. Half-life 4.0 min (dog), 2.9 min (monkey), 2.0 min (rat) |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of DSIP were used in human studies?
In the studies listed here, people were given from 25 nmol/kg IV, one time up to 100 nmol/kg IV bolus, two doses in one day (surgery patients). The amount used most often was 25 nmol/kg IV, nightly for 3 to 4 nights. These are what study teams chose for their participants under supervision.
Where do these DSIP numbers come from?
From 8 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Human trials.
Is this a recommendation for how much DSIP to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.