PT-141 dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 7 published studies are one click away.
Human trials Melanocortin Also called Bremelanotide
Common use ranges
Mostly from the official drug label or its main trials, plus clinic protocols. Label sets 1.75 mg. One clinic source gives the 0.5 to 2 mg ladder.
- Half-life
- about 2.7 hours (range 1.9 to 4.0 hours)
- How it is taken
- subcutaneous injection
- How long people use it
- No cycle. Used as needed, up to 8 times a month.
- Mixing used for the units
- 10 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 50 mcg.
Pick your vial size and how much water you add. The units below change to match.
10 mg vial + 2 mL water: 1 unit = 50 mcg
| Tier | Each dose | Syringe units10 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 500 mcg | 10 units 0.10 mL | once a day | As needed, a test dose to check nausea. No more than 1 a day. | 20 days |
| Typical [2] | 1.25 mg | 25 units 0.25 mL | once a day | As needed, 45 to 60 minutes before. No more than 1 a day. | 8 days |
| Label dose [3] | 1.75 mg | 35 units 0.35 mL | once a day | As needed, at least 45 minutes before. Max 1 in 24 hours, max 8 a month. | 5 days |
| Higher [4] | 2 mg | 40 units 0.40 mL | once a day | As needed, mostly men in clinic use. No more than 1 a day. | 5 days |
Good to know
- Use as needed, at least 45 minutes before.
- Nausea hit 40 percent in the label trials. It got better for most by the second dose.
- Blood pressure rises for a few hours after each dose. Not for uncontrolled high blood pressure.
- Dark skin patches can show up with frequent use.
- Clinics step up 0.5, then 1.25, then 1.75 or 2 mg.
- Brand pen is 1.75 mg. Compounded or research vials are usually 10 mg.
Sources for these amounts
- Starting: FormBlends, PT-141 dosage protocols
- Typical: FormBlends, PT-141 dosage protocols
- Label dose: Vyleesi prescribing information (FDA, 2019) ยท FormBlends, PT-141 dosage protocols
- Higher: FormBlends, PT-141 dosage protocols
How long people use it: Vyleesi prescribing information (FDA, 2019)
Take the PT-141 chart with you
Get a one-page printable chart for PT-141, with the syringe units for each vial and water mix. We can also email you when a new PT-141 study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 7 published studies
Amounts given to people in studies
How it was given: Under the skin (SC). Early trials used a nasal spray.
Amounts given to animals in studies
Every study used for this page
Proof grade: Human trials. Tested in randomized human trials. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 152265022004 | Rat, ovariectomized Long-Evans females (about 140 females total across tests) | 50, 100, 200 mcg/kg (PMC full text, read via PMC page) | SC | Single dose 5 min before each test | Single-session behavior tests | Selectively raised solicitation behavior. Rat body weight not stated, assumed ~0.25 kg |
| PMID 149634712004 | Human, healthy men and ED patients (n not in abstract) | Not stated in the abstract | Intranasal | Single dose | Single dose | Erections about 30 min after dose, flushing and nausea common |
| PMID 158335222005 | Human, ED, crossover (n=19) | 7.5 mg PT-141 plus 25 mg sildenafil | Intranasal | Single dose | Single dose per arm | PT-141 plus sildenafil gave greater erectile response than sildenafil alone |
| PMID 182069192008 | Human, ED non-responders to sildenafil (n=342) | 10 mg intranasal vs placebo | Intranasal | 45 min to 2 h before sexual activity, at least 16 attempts | Not in abstract | Positive response 33.5% vs 8.5% |
| PMID 281893612017 | Human, healthy (n=24, 12 men and 12 women) | 20 mg single doses on days 1, 4, 7, with or without ethanol 0.6 g/kg | Intranasal | 3 single doses | 7 days | Safe with alcohol. Abstract says 20 mg intranasal has exposure about 1 to 2 times the SC phase 3 dose |
| PMID 271817902016 | Human, premenopausal women, phase 2b (efficacy n=327) | 0.75, 1.25, 1.75 mg vs placebo | SC (self-injected) | As desired | 12 weeks | 1.25/1.75 pooled beat placebo: +0.7 vs +0.2 satisfying events per month |
| PMID 315998402019 | Human, premenopausal women with HSDD, two phase 3 trials, RECONNECT (n=1267 randomized) | 1.75 mg vs placebo | SC | As needed | 24 weeks | Desire score +0.35, distress -0.33 vs placebo (integrated) |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of PT-141 were used in human studies?
In the studies listed here, people were given from 0.75 mg, as needed up to 20 mg nasal spray, single dose (safety study). The amount used most often was 1.75 mg, as needed. These are what study teams chose for their participants under supervision.
Where do these PT-141 numbers come from?
From 7 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Human trials.
How long does PT-141 stay in the body?
Its half-life is about 2.7 hours (range 1.9 to 4.0 hours) in people. Half-life is how long it takes for half of a dose to leave the blood. The effect can last longer than that.
Is this a recommendation for how much PT-141 to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.