Kisspeptin-10 dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 8 published studies are one click away.
Small human studies Reproductive axis Also called Metastin 45-54
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Very few sources. No drug label and no tested shot amount. The only shot amounts are user reports. Human studies gave it into a vein, which does not convert to a shot.
Sources disagree, or there are very few. The amounts below come from a small number of guides, and they do not line up well. Treat every number on this page as uncertain, and check each source yourself.
- Half-life
- about 4 minutes
- How it is taken
- subcutaneous injection
- How long people use it
- Not stated by the sources.
- Mixing used for the units
- 5 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 25 mcg.
Pick your vial size and how much water you add. The units below change to match.
5 mg vial + 2 mL water: 1 unit = 25 mcg
| Tier | Each dose | Syringe units5 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Starting [1] | 100 mcg | 4 units 0.04 mL | once a day | 100 mcg, daily or only when needed | 6+ weeks |
| Higher [2] | 200 mcg | 8 units 0.08 mL | once a day | 200 mcg, daily or only when needed | about 4 weeks |
Good to know
- The kisspeptin used in fertility trials under the skin was kisspeptin-54, a longer form.
Sources for these amounts
- Starting: Outliyr, kisspeptin-10 report
- Higher: Outliyr, kisspeptin-10 report
Half-life: Jayasena et al 2011, J Clin Endocrinol Metab
Take the Kisspeptin-10 chart with you
Get a one-page printable chart for Kisspeptin-10, with the syringe units for each vial and water mix. We can also email you when a new Kisspeptin-10 study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 8 published studies
Amounts given to people in studies
How it was given: Into a vein (IV)
Short lab studies, 3 to 11 people per group.
Every study used for this page
Proof grade: Small human studies. Only small or uncontrolled human studies. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 216328072011 | Human, healthy men (bolus n = 6 at the 1 mcg/kg level, infusions n = 4 per arm) | Bolus 0.01-3.0 mcg/kg. Infusion 1.5 mcg/kg/h and 4 mcg/kg/h | IV bolus and IV infusion | Single bolus. Continuous infusion | Infusion up to 22.5 h | Maximal LH response at 1 mcg/kg bolus. 3 mcg/kg gave a smaller response. 1.5 mcg/kg/h raised LH pulse frequency 0.7 to 1.0/h |
| PMID 219767242011 | Human, healthy men and women (n = 4-5 per group) | Men: IV bolus LH response at doses as low as 0.3 nmol/kg, FSH as low as 1.0 nmol/kg. Women follicular: maximal 10 nmol/kg IV bolus, 32 nmol/kg SC bolus, 720 pmol/kg/min IV infusion. Women preovulatory: 10 nmol/kg IV bolus | IV bolus, SC bolus, IV infusion | Single | Acute | Men and preovulatory women responded. Follicular-phase women did not respond to any route |
| PMID 229563462012 | Human, women: early follicular (n = 10), post-menopausal (n = 6), on contraceptives (n = 8) | 0.3 mcg/kg | IV | Single | Sampled for 60 min after | LH rose in follicular, post-menopausal and progestogen groups, not combined pill. FSH rose only post-menopause |
| PMID 231532702013 | Human, men with type 2 diabetes (n = 5, infusion in 4) and healthy men (n = 7) | Bolus 0.3 mcg/kg. Infusion 4 mcg/kg/h | IV bolus and IV infusion | Single bolus. Infusion for 11 h, 5 days later | 11 h infusion | LH rose (3.9 to 20.7 IU/l) and testosterone 8.5 to 11.4 nmol/l in hypogonadal diabetic men |
| PMID 260893022015 | Human, healthy men (n = 5 per dose group) | 0.1, 0.3 and 1.0 nmol/kg/h (also given for kisspeptin-54 and GnRH) | IV infusion | One 3-h infusion per study visit, visits at least a week apart | 3 h | Kisspeptin-10 and -54 gave similar LH and FSH. GnRH about 3-fold higher than kisspeptin-10 |
| PMID 425498272026 | Human, healthy men (study 1 n = 7, study 2 n = 4, study 3 n = 7, plus 12 controls) | Acute 1.25-10.0 nmol/kg/h. Continuous 180 nmol/h for 5 days. Daily 8-h infusion at 150 nmol/h for 12 days. Bolus 1 nmol/kg after 12 days | SC infusion | Continuous x 5 days, or 8 h on and 16 h off | 5 days or 12 days | Acute infusion dose-dependent. 5-day continuous: gonadotropins back to vehicle. Daily 8-h infusions kept LH up for 12 days |
| PMID 422304852026 | Human, healthy men (n = 3) | 12.5 mcg/kg/h | IV infusion | Continuous | 24 h | LH rose 5- to 8-fold, peaked at 12-20 h, then fell 13-47% by end of infusion |
| PMID 300463072018 | Human, boys in Tanner stages I-V and adult men (n = 5 per group) | Not stated in the abstract | IV bolus | Single | Sampled 30 min before, 120 min after | LH/testosterone response absent in early puberty, present from Tanner stage V |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
What amounts of Kisspeptin-10 were used in human studies?
In the studies listed here, people were given from 0.01 mcg/kg IV up to 12.5 mcg/kg per hour IV for 24 hours. The amount used most often was 0.3 mcg/kg IV. These are what study teams chose for their participants under supervision.
Where do these Kisspeptin-10 numbers come from?
From 8 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Small human studies.
How long does Kisspeptin-10 stay in the body?
Its half-life is about 4 minutes in people. Half-life is how long it takes for half of a dose to leave the blood. The effect can last longer than that.
Is this a recommendation for how much Kisspeptin-10 to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.