FOXO4-DRI dose range
The amounts people commonly use, from the low end to the high end, with syringe units, schedule and half-life. The 7 published studies are one click away.
Animal studies only Longevity Also called FOXO4 D-Retro-Inverso, FOXO4-DRI peptide
Common use ranges
From user guides and clinic write-ups. No drug label exists, and no study has tested these amounts in people. Sources disagree badly. One guide uses 250 to 500 mcg a day for 16 weeks. Another uses 3 to 25 mg a shot every other day for 3 to 6 shots. The only published protocol was in mice.
Sources disagree, or there are very few. The amounts below come from a small number of guides, and they do not line up well. Treat every number on this page as uncertain, and check each source yourself.
- Half-life
- Not measured in any published study
- How it is taken
- subcutaneous injection
- How long people use it
- 16 weeks (daily ladder), or 3 to 6 shots repeated 1 to 3 times a year (short course).
- Mixing used for the units
- 10 mg vial + 2 mL water. 1 unit on a U-100 insulin syringe = 50 mcg.
Pick your vial size and how much water you add. The units below change to match.
10 mg vial + 2 mL water: 1 unit = 50 mcg
| Tier | Each dose | Syringe units10 mg vial + 2 mL water | How often | Schedule | Vial lastsat this tier |
|---|---|---|---|---|---|
| Daily ladder, start [1] | 250 mcg | 5 units 0.05 mL | once a day | 250 mcg a day for weeks 1 to 4 | about 6 weeks |
| Daily ladder, top [2] | 500 mcg | 10 units 0.10 mL | once a day | 500 mcg a day for weeks 9 to 16 | 20 days |
| Short course [3] | 3 mg | 60 units 0.60 mL | 3x a week | 3 mg or more a shot, every other day, for 3 to 6 shots in total | 7 days |
Sources for these amounts
- Daily ladder, start: Peptide Dosing Protocols, FOXO4-DRI
- Daily ladder, top: Peptide Dosing Protocols, FOXO4-DRI
- Short course: Peptide Protocol Wiki, FOXO4-DRI dosing
How long people use it: Peptide Dosing Protocols, FOXO4-DRI ยท Peptide Protocol Wiki, FOXO4-DRI dosing
Half-life: Baar et al 2017, Cell, the paper that created the peptide
Take the FOXO4-DRI chart with you
Get a one-page printable chart for FOXO4-DRI, with the syringe units for each vial and water mix. We can also email you when a new FOXO4-DRI study is published.
This page shows what labels, clinics and users report, and what studies gave. It is not medical advice and not a recommendation for anyone. Many of these compounds are not approved for human use. Check your own medicines and lab work with a licensed clinician before using anything.
See the science: 7 published studies
No human dose data. No published human study of FOXO4-DRI states an amount given. Every figure on this page comes from animal studies.
Amounts given to animals in studies
Read this first. No study has given this to a person. Every amount is from mice, or from cells in a dish at 25 micromolar.
Every study used for this page
Proof grade: Animal studies only. No human dose data has been published. Amounts are quoted as each study reported them. Where the abstract does not state an amount, the row says so.
| Study | Who was studied | Amount given, as reported | Route | How often | How long | What the authors reported |
|---|---|---|---|---|---|---|
| PMID 28340339Baar et al, Cell 2017 | Mouse, doxorubicin-treated (PMC full text, figure legend) | 5 mg/kg | Into a vein | Every other day, 3 doses (day 1, 3, 5) | 5 days of dosing | Blocked the damage doxorubicin did to the body |
| PMID 28340339Baar et al, Cell 2017 | Mouse, naturally aged (PMC full text, figure legend) | 5 mg/kg | Into the belly | Every other day, 3 doses | Checked 30 days after the first dose | Fitness, fur thickness and kidney function came back |
| PMID 31959736Zhang et al, Aging 2020 | Mouse, aged males 20 to 24 months (PMC full text) | 5 mg/kg | Into the belly | Every other day, 3 doses | Checked 30 days later | Testosterone rose, aged Leydig cells were cleared |
| PMID 35510614Han et al, J Cell Mol Med 2022 | Mouse, bleomycin lung scarring (PMC full text) | 5 mg/kg | Into the belly | 3 doses, on days 14, 16 and 18 | Checked day 21 | Less lung scarring than untreated mice |
| PMID 39994346Kong et al, Commun Biol 2025 | Human keloid and normal skin cells in a dish (PMC full text) | 25 micromolar | In the cell medium | Once, left in the medium | 3 days | Killed the aged cells, half-killing point 34 micromolar |
| PMID 33996787Huang et al, Front Bioeng Biotechnol 2021 | Human cartilage cells in a dish, healthy donors (PMC full text) | 25 micromolar | In the cell medium | Once, left in the medium | 5 days | Removed more than half the cells in the aged batch |
| PMID 39025385Li et al, Exp Gerontol 2024 | Mouse, aged males | Not stated in the abstract | Not in abstract | Not in abstract | Not in abstract | Better sperm production in old mice |
How to read the study numbers
- One study, one group. Each figure is what one team chose for its own participants or animals.
- Route matters. An amount given into a vein (IV) is not the same as the same amount under the skin, in the nose or by mouth.
- Animals are not small people. An animal amount is shown as the study gave it. It is not a human amount.
- Short studies. Many studies ran days or weeks. They do not show what happens over longer use.
Common questions
Is there a human dose for FOXO4-DRI?
No published human study of FOXO4-DRI states an amount given. The figures on this page come from animal studies only.
Where do these FOXO4-DRI numbers come from?
From 7 published studies, each linked to its PubMed or ClinicalTrials.gov record. Every figure was checked against the study abstract or its open full text. Proof grade: Animal studies only.
How long does FOXO4-DRI stay in the body?
No published study has measured the half-life of FOXO4-DRI, so nobody knows exactly how long one dose stays in the blood.
Is this a recommendation for how much FOXO4-DRI to use?
No. This page shows the amounts reported by drug labels, clinics and users, next to what researchers gave in studies. It is not medical advice and not a recommendation for anyone. Talk to a licensed clinician before using any of it.